attenuation of cisplathin-induced toxic oxidative stress by propofol

background antioxidant effects of propofol (2, 6-diisopropylphenol) were evaluated against cisplatin-i‎nduced oxidative stress in rat. objectives in this experimental study, 20 male rats were equally divided into 4 groups (5 rats each), and were treated by propofol (10 mg/kg/day, ip), or cisplatin (7 mg /kg/day, ip), or both. conclusions it is concluded that oxidative ‎damage is the mechanism of cisplatin toxicity, which can be recovered by propofol.‎ results oxidative stress induced by cisplatin, was evident by a significant increase in lpo and decrease in ttg and tac. propofol recovered ‎cisplatin -induced changes in tac, ttg and lpo in blood. materials and methods g‎roup one was control, while group 2 was given cisplatin (7 mg /kg/day, ip). animals of the third group received only propofol (10 mg/kg/day, ip). group 4 was given propofol with cisplatin once per day for 7 days. after treatment, blood urea nitrogen, creatinine levels, and oxidative stress m‎arkers such as total thiol groups (ttg), lipid peroxidation (lpo), and total antioxidant ‎capacity (tac) were measured.